|
Periapical Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of WNT3, WNT3A and WNT5A in AP tissues was significantly higher than in control tissues, and inversely correlated with the expression of SERPINB1, COL1A1 and TIMP1 (P < 0.05).
|
31831777 |
2019 |
|
Nonspecific interstitial pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The IMU-COLV mice presented with increased tissue elastance and a nonspecific interstitial pneumonia (NSIP) histologic pattern in the lung, combined with the thickening of the small and medium intrapulmonary arteries, increased Col V fibers, and increased COL1A1, COL1A2, COL3A1, COL5A1, and COL5A2 gene expression.
|
31829272 |
2019 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subjects with low COL1A1, low BMP-6, and high IL-6Rα levels had a hazards ratio of 5.097 for incident CHD risk (p = 0.019), compared with those without.
|
31812227 |
2020 |
|
Osteogenesis Imperfecta
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
None of them could be classified as affected by OI or by any of the three recognized EDS variants associated with COL1A1/COL1A2.
|
31794058 |
2020 |
|
Ehlers-Danlos Syndrome
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
None of them could be classified as affected by OI or by any of the three recognized EDS variants associated with COL1A1/COL1A2.
|
31794058 |
2020 |
|
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, by testing genes shared by several functional gene-signatures for their association with event-free survival in a validation cohort (n = 272), we identified five genes (ASPN, BGN, COL1A1, RRM2 and TYMS)-three of which are included in commercially available prognostic tests-whose high expression was significantly associated with worse outcome exclusively in T2E-negative PCa.
|
31732966 |
2020 |
|
Angle Closure Glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A significant increase was observed in the transcripts of MCP-1, TGF-β2, and SPARC in POAG and PACG (P < 0.05); CTGF, TGF-β1, LOX, LOXL2, ELN, COL1A1, and α-SMA in PACG (P < 0.05) compared with control.
|
31725165 |
2019 |
|
Primary angle-closure glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A significant increase was observed in the transcripts of MCP-1, TGF-β2, and SPARC in POAG and PACG (P < 0.05); CTGF, TGF-β1, LOX, LOXL2, ELN, COL1A1, and α-SMA in PACG (P < 0.05) compared with control.
|
31725165 |
2019 |
|
Lobstein Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Generation of a patient-specific induced pluripotent stem cell line, KSCBi006-A, for osteogenesis imperfecta type I with the COL1A1, c.3162delT mutation.
|
31715426 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
After analyzing the RNA-Seq data of PTC patients from the Cancer Genomic Atlas, 497 differentially expressed PTC genes were found to be associated with HT, of which protein tyrosine phosphatase receptor type C (PTPRC), KIT, and COL1A1 were associated with tumor size and lymph node metastasis (p < 0.05).
|
31686862 |
2019 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
After analyzing the RNA-Seq data of PTC patients from the Cancer Genomic Atlas, 497 differentially expressed PTC genes were found to be associated with HT, of which protein tyrosine phosphatase receptor type C (PTPRC), KIT, and COL1A1 were associated with tumor size and lymph node metastasis (p < 0.05).
|
31686862 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
After analyzing the RNA-Seq data of PTC patients from the Cancer Genomic Atlas, 497 differentially expressed PTC genes were found to be associated with HT, of which protein tyrosine phosphatase receptor type C (PTPRC), KIT, and COL1A1 were associated with tumor size and lymph node metastasis (p < 0.05).
|
31686862 |
2019 |
|
Hashimoto Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
After analyzing the RNA-Seq data of PTC patients from the Cancer Genomic Atlas, 497 differentially expressed PTC genes were found to be associated with HT, of which protein tyrosine phosphatase receptor type C (PTPRC), KIT, and COL1A1 were associated with tumor size and lymph node metastasis (p < 0.05).
|
31686862 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
After analyzing the RNA-Seq data of PTC patients from the Cancer Genomic Atlas, 497 differentially expressed PTC genes were found to be associated with HT, of which protein tyrosine phosphatase receptor type C (PTPRC), KIT, and COL1A1 were associated with tumor size and lymph node metastasis (p < 0.05).
|
31686862 |
2019 |
|
Pelvic Organ Prolapse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although there was no significant association between the COL3A1 SNP and POP, there was a trend toward significance for COL14A1 SNP (rs2305603), COL4A2 SNP (rs74941798), two COL1A1 SNPs (rs2586488 and rs2249492) and three COL18A1 SNPs (rs1050351, rs56335679, and rs55690336), and POP.
|
31663982 |
2020 |
|
Malignant neoplasm of stomach
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We found that COL1A1-014 was frequently upregulated in GC tissues as well as cells.
|
31650323 |
2020 |
|
Stomach Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We found that COL1A1-014 was frequently upregulated in GC tissues as well as cells.
|
31650323 |
2020 |
|
Osteogenesis Imperfecta
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
More than 85% Osteogenesis Imperfecta (OI) patients have pathogenic variants in COL1A1/A2.
|
31568717 |
2019 |
|
OVERLAP CONNECTIVE TISSUE DISEASE
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, transgenic mice overexpressing CrkII under control of the alpha-1 type I collagen promoter exhibited a reduced bone mass phenotype.
|
31554784 |
2019 |
|
Ehlers-Danlos Syndrome
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This raises the question of the association of COL1A1 p.(Arg312Cys) with arterial complications and the need for a gene panel including not only the usual genes tested in search of classical or vascular EDS but also COL1A1.
|
31531849 |
2020 |
|
Malignant tumor of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Bone Morphogenetic Protein 1 Targeting COL1A1 and COL1A2 to Regulate the Epithelial-Mesenchymal Transition Process of Colon Cancer SW620 Cells.
|
31492296 |
2020 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Bone Morphogenetic Protein 1 Targeting COL1A1 and COL1A2 to Regulate the Epithelial-Mesenchymal Transition Process of Colon Cancer SW620 Cells.
|
31492296 |
2020 |
|
Parastomal hernia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
α1 (III) procollagen expression levels were significantly increased in patients with PH, while no marked difference in α1 (I) procollagen mRNA expression levels were observed in patients with or without PH.
|
31485641 |
2019 |
|
Osteoporosis, Postmenopausal
|
0.120 |
AlteredExpression
|
disease |
BEFREE |
The transfection of miR-218-5p mimics into PMOP BMMSCs significantly upregulated COL1A1 at 14th and 21st day post-induction, but not at 7th day.
|
31478244 |
2020 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, the relationship between SM α-actin and type 1 collagen expression (COL1A1), a major extracellular matrix protein important in liver fibrosis, is investigated with the results demonstrating that knockout of SM α-actin leads to reduced liver fibrosis and COL1 expression.
|
31476284 |
2019 |